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Fermented Foods Improve Mental Health | MSG and Free Glutamate: Lurking Everywhere
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Dr. Mercola: Could Eating More Fermented Foods Help Improve Mental Health?
By Dr. Joseph Mercola
Mercola.com
April 27, 2024

Fermented foods like sauerkraut and kimchi are powerful allies to your mental health, courtesy of the neuroactive microbes and molecules they contain.1 Microbes and their metabolites, created during fermentation modulate the microbiota-gut-brain axis, which involves neural, immune, endocrine and metabolic pathways.2

Writing in Neuroscience & Biobehavioral Reviews, researchers with University College Cork (UCC) in Ireland and colleagues reasoned that fermented foods “offer an affordable dietary intervention strategy” for better mental health.3

Their review highlights how different types of fermented food not only have the potential to alter the makeup of microbiota in your gut but also influence the immune system and microbiota-gut-brain axis, with profound effects on your brain.

Fermentation — An Ancient Tool Valued for Modern-Day Mental Health

Many cultures around the world have relied on food fermentation since ancient times to increase the shelf-life of food. Fermentation also makes food more flavorful while helping to control potentially disease-causing microorganisms and improving foods’ digestibility.4

The process involves the conversion of carbohydrates into alcohol or organic acids using microorganisms like yeasts and bacteria under anaerobic conditions. This leads to the production of beneficial compounds now known to boost physical and mental health.

“Although ancient in origin, fermented foods are now seen as conduits for introducing beneficial microbes and molecules. Moreover, fermented foods are applicable therapeutics across various socioeconomic sectors given their potential affordability and cross-cultural accessibility,” the review explained.5

Fermented foods are rich in phytochemicals and microbe metabolites that include neurotransmitters and neuromodulators. These compounds stimulate pathways of the microbiota-gut-brain axis, including those of the immune system and neuroendocrine, enteric nervous and circulatory systems. When fermented foods are digested, they also produce compounds capable of modulating intestinal barrier and blood brain barrier permeability.6

Fermented foods may also help block dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, the system responsible for the management of stress, which has also been linked to multiple neuropsychiatric disorders.7

Researchers with APC Microbiome Ireland at UCC previously investigated the influence of a psychobiotic diet on the microbial profile and mental health of 45 adults.8 Participants were randomized to eat either a psychobiotic diet or a control diet for four weeks. The psychobiotic diet included fruits and vegetables high in prebiotic fiber, including onions, leeks, cabbage, apples and bananas, along with fermented foods, such as sauerkraut and kefir.9

After four weeks, those following the psychobiotic diet had a reduction in perceived stress. Those who followed the psychobiotic diet the most had the greatest decreases in stress. Further, significant changes were found in 40 different chemicals, along with subtle changes in microbial makeup. Professor John Cryan, one of the study’s lead authors who also worked on the featured Neuroscience & Biobehavioral Reviews paper, said in a UCC news release:10

“Although the microbiome has been linked to stress and behavior previously, it was unclear if by feeding these microbes demonstratable effects could be seen. Our study provides one of the first data in the interaction between diet, microbiota and feelings of stress and mood.

Using microbiota targeted diets to positively modulate gut-brain communication holds possibilities for the reduction of stress and stress-associated disorders, but additional research is warranted to investigate underlying mechanisms.”

Virtually Any Fermented Food May Improve Brain Health

In the early stages of the research, study author Ramya Balasubramanian and colleagues compared sequencing data from more than 200 fermented foods in an effort to determine which are most beneficial for the brain. Nearly all of them showed promise, according to Balasubramanian, who said in a news release:11

“I expected only a few fermented foods would show up, but out of 200 fermented foods, almost all of them showed the ability to exert some sort of potential to improve gut and brain health … Fermented sugar-based products and fermented vegetable-based products are like winning the lottery when it comes to gut and brain health.

… For all that we see on sugar-based products being demonized, fermented sugar takes the raw sugar substrate, and it converts it into a plethora of metabolites that can have a beneficial effect on the host.

So even though it has the name ‘sugar’ in it, if you do a final metabolomic screen, the sugar gets used by the microbial community that’s present in the food, and they get converted into these beautiful metabolites that are ready to be cherry picked by us for further studies.”

The Neuroscience & Biobehavioral Reviews paper outlined a wide range of fermented foods that may be beneficial. Among them:

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Both food substrate and environmental conditions alter the fermented food microbiome and therefore its potential health effects. According to the review:13

“Fermented foods are diverse in their preparation, substrate category and type of fermentation. This can influence the microbiota and the molecular composition of fermented foods.

Subsequently, these components can influence the communication between the gut and the brain resulting in modulation of the intestinal barrier and blood brain barrier, peripheral and central immune system and nervous system and thereby modulating the intestinal milieu, general gut and brain health.”

Fermented Foods Help Ward Off Depression

Lactobacillus, found in fermented foods like yogurt, kefir, kimchi and sauerkraut, has been dubbed a “psychobiotic”14 because of its effects on mental health, particularly anxiety and depression. Lactobacillus bacteria help dampen stress responses and prevent depression and anxiety, in part, by modulating your immune system.15

Further, a healthy gut microbiome also depends on the consumption of fermented foods. A study assigned 36 adults to consume a diet high in fermented foods or high-fiber foods for 10 weeks. Those consuming fermented foods had an increase in microbiome diversity as well as decreases in markers of inflammation.16

In another example, Lactobacillus was found to produce gamma aminobutyric acid (GABA), a neurotransmitter that inhibits excessive neuronal firing, helping to induce a natural state of calm,17 in animal studies,18 while also reducing depression-related behavior.19

A meta-analysis of cohort studies, involving 83,533 people, also found a significant association between consuming fermented dairy foods, including cheese and yogurt, and a decreased risk of depression.20 The study suggested the gut-brain axis may explain the link between fermented dairy foods and depression, as probiotic-rich fermented foods may help:21

Lower inflammation in the gut
Make the gut barrier stronger
Reduce stress responses via the HPA axis
Alter GABA receptor expression
One study using brain scans found that consuming fermented milk containing a variety of probiotics can lessen brain activity related to seeing sad or angry faces. Another study found that women who took probiotics had lower depression scores.22

Fermented Foods May Help Preserve Mental Health

Dietary interventions based on so-called “psychobiotics” were described as a “novel nutritional approach targeting gut microbiota for managing cognitive performance and preventing memory decline across the lifespan.”23 The review, published in Food Research International, suggests that fermented foods may help preserve mental health.

Further, feeding your microbes with a psychobiotic diet — one that’s rich in prebiotic and fermented foods — can also reduce stress and possibly stress-related disorders. The study authors stressed the benefits of using whole, fermented foods:24

“Although the more traditional psychobiotic candidates, such as probiotic and prebiotic supplementation, are promising approaches, using whole dietary approaches offers a number of advantages.

This includes the benefits associated with nutritional needs met primarily through whole diet, a more accessible way due to the necessity to consume a food daily, costs of supplemental products as well as the potential synergistic effects in the microbiota that could be elicited by complex diets.”

Interestingly, they also found that tryptophan metabolism may be one underlying mechanism behind fermented foods’ stress-relieving effects. “Tryptophan metabolism has been shown to be closely regulated by the microbiota and can serve as important bioactive messengers in the microbiota-brain communication,” the researchers explained, adding that it’s also involved in many brain-related disorders.25

How to Make Fermented Foods at Home

https://www.youtube.com/watch?v=XGAisGdDfqc

Given the numerous mental health benefits of fermented foods, if you haven’t yet incorporated them into your diet, now is an excellent time to start. Fermented vegetables are both simple and cost-effective to prepare at home. While you can find fermented foods at supermarkets and health food stores, many commercial options, such as yogurt and kefir, are not healthy.

Many of these products contain high levels of sugar, artificial sweeteners and additives, with a relatively low content of beneficial bacteria. The pasteurization process used in commercial products to extend their shelf life actually destroys the beneficial bacteria they’re supposed to contain.

To reap the maximum health benefits, either purchase raw (unpasteurized) versions of these foods at a health food store or food co-op, or make them yourself. Consuming a diverse range of fermented foods is beneficial, as each offers a unique set of beneficial bacteria.

Fortunately, making fermented foods at home is simpler than it might seem. It doesn’t require extensive time in the kitchen. Start by getting some wide-mouth canning jars and filtered water, along with select organic vegetables of your choice for fermenting. After packing your jars, the only step left is to wait a few days for the vegetables to ferment, or “ripen.”

You can view a step-by-step guide in the video above. As demonstrated, you’ll see that culturing vegetables is simple and cost-effective. You can also make your own homemade yogurt and kefir. If you don’t eat fermented foods on a regular basis, a probiotic supplement shouldn’t be considered a replacement for whole, fermented foods.

https://www.lewrockwell.com/2024/04/jose...al-health/

MSG and Free Glutamate: Lurking Everywhere
By Sally Fallon Morell
Mercola.com
April 26, 2024

Some time ago, on a trip to British Columbia, I ate in a local restaurant. When eating out, I always try to order something simple, without a gravy or sauce, since these sauces are bound to contain MSG.

So, I ordered a plain crab cake with rice and vegetables — no sauce, no mayo. Boy, did that crab cake taste good! About midnight I knew why. I woke up with a dry mouth, a terrible thirst and a headache. The next day I felt sore all over, like I’d been in a fight. My hands felt like they had arthritis.

Fortunately, since I don’t eat food containing MSG very often, the symptoms cleared by the next day. Unfortunately, I attended a reception that evening, and since I had skipped lunch and was hungry, I ate things I shouldn’t have, including a peanut sauce I am sure came from a can. That night, the same thing happened, and the next day I was stiff and sore from head to toe.

Of course, I knew the reason why and just resolved to be more careful going forward. But suppose I was a person who ate a lot of processed or restaurant food and didn’t know about the dangers of MSG. I would feel awful all the time: headache, dry mouth, excessive thirst, and aches and pains like arthritis.

I might be told I had the disease du jour: fibromyalgia. But there is no treatment for fibromyalgia so I would probably be treated for the runner-up disease du jour: Lyme’s disease. The treatment for Lyme’s disease is courses of antibiotics, which would probably make my condition worse.

If I complained to the doctor about the dry mouth and thirst, I would be tested for diabetes; and if I sought treatment for headaches, I’d end up on some pretty powerful pain killers.

Which brings us to the question: could all these conditions, especially the rheumatism-like achiness that plagues so many people, be due to MSG and similar substances added to virtually all processed food?

Glutamine Versus Glutamate

For example, MSG allows food manufacturers to make something that resembles gravy — which we make at home with good drippings, flour and genuine bone broth — with water, a thickener, artificial coloring and artificial flavors, especially MSG.

Apologists for MSG point out that it derives from glutamine, an amino acid needed for protein synthesis, immunity, liver health, detoxification and maintenance of acid-alkaline balance, among many other roles.

Our bodies can make glutamine; however, in times of rapid growth or healing — especially healing of the gut — we need more glutamine than we can make and must get it from food. Homemade bone broth is an excellent source, one explanation for bone broth’s reputation as a healing food.

Glutamine is a precursor to glutamate, an important neurotransmitter, for which we have receptors in the brain and all over the body. Apologists for MSG argue that the additive is not really different from glutamate (or its cousin glutamic acid).

For example, journalist Liz Roth-Johnson writes, “Despite their different names, glutamate, glutamic acid, and monosodium glutamate are essentially the same molecule and behave the same way in our bodies.” She provides the following diagram.

https://lrc-cdn.s3.amazonaws.com/assets/...20x365.png

Roth-Johnson notes that ripe tomatoes and aged cheese contain high levels of glutamate, so what could be the problem with MSG? The problem is that most people don’t get headaches and arthritis-like symptoms when they eat ripe tomatoes and aged cheese.

One explanation is that the sodium molecule added to glutamate makes it a very different molecule — after all, adding chlorine to sodium to make nutritious salt makes chlorine very different from poisonous chlorine gas! Small differences in molecules can make huge differences in the body.

Free Glutamate Can Overload Your System

Free glutamate is formed during fermentation — of milk into cheese, of soybeans into soy sauce, etc. That’s what gives these foods their delicious meat-like umami taste. Most people can eat small amounts of slowly and naturally fermented soy sauce without problem, but react strongly to cheap soy sauce made by rapid protein hydrolysis with added MSG.

Another difference: most of the glutamate in our body does not come from free glutamate in our food but from the breakdown of protein into its separate amino acids. It’s a good assumption that these enter the bloodstream more slowly than MSG added to food, or even to glutamate naturally formed in food, so that their transformation into neurotransmitters is more controlled.

Eating foods containing MSG or a lot of added free glutamate, can overwhelm the system, so to speak. And free glutamate is everywhere, I mean everywhere, usually not labeled but lurking in other food additives.

Ingredients That Contain Free Glutamate

Here’s a list of ingredients that contain free glutamate in one form or another:

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And these are foods that can contain a lot of free glutamate formed during processing:

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And these are foods that extremely sensitive people have reacted to:

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Fermented Foods May Trigger Reactions if You’re Sensitive

Furthermore, these sensitive souls need to avoid anything fermented, including natural cheese, naturally fermented soy sauce and homemade sauerkraut, and even tomato paste.

Interestingly, the late Jack Samuels, creator of truthinlabeling.org (which created the above lists), told me that he could eat cheese made with old-fashioned animal rennet without problem, but reacted strongly to cheese made with vegetarian rennet (which is produced by genetically modified bacteria).

I always purchase organic herbs and spices, often not reading the labels. But I looked carefully at the label of some organic chili powder I recently bought and was shocked to read that it contained “organic rice concentrate.”

Rice concentrate is not in any of the above lists, but it is obviously a processed ingredient and why would the company add it to chili powder unless it contributed some kind of zip to the flavor? Just shows you can’t be too careful! Always read labels!

But back to the main point: if you are suffering from any kind of chronic pain or discomfort, try limiting yourself exclusively to whole natural foods that you have prepared yourself. I’m betting you will see an improvement without taking any drugs.

https://www.lewrockwell.com/2024/04/no_a...verywhere/
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